The Effects of ADHD Medications on Youth Growth Trajectories

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that affects many children and adolescents. While there are various treatment options available, including medication, it is essential to understand the potential effects these medications may have on youth growth trajectories. Recent research has shed light on the differences in growth patterns among youth prescribed different ADHD medications, specifically lisdexamfetamine dimesylate (LDX; Vyvanse) and delayed release/extended-release methylphenidate (DR/ER-MPH; Jornay PM).

The Impact on Weight Trajectory

A study conducted by Karl Weddige, PhD, of Ironshore Pharmaceuticals, investigated the weight trajectories of youth with ADHD who were prescribed either LDX or DR/ER-MPH. The findings revealed a significant difference in weight gain among the two medication groups. Youth who took DR/ER-MPH experienced a greater weight trajectory in the first year after starting treatment, compared to those prescribed LDX (estimated post-index slope: 2.65 for LDX vs 7.22 for DR/ER-MPH, with a significant difference of P<0.0001).

After one year of medication use, the model-adjusted average weight for youth on LDX was approximately 43 kg, whereas those on DR/ER-MPH reached around 43.4 kg.

Considerations and Insights

These findings provide valuable insights for clinicians and parents considering medication options for youth with ADHD. Understanding the potential impact on weight trajectories is crucial in the decision-making process. However, it is essential to note that weight gain is just one aspect of medication effects and should be considered alongside other factors.

It is important to evaluate each individual case and consider the specific needs and potential side effects of the medications. Factors such as the severity of ADHD symptoms, other existing health conditions, and individual responses to different medications should be taken into account.

Additionally, it is worth mentioning that these results are based on a specific study comparing LDX and DR/ER-MPH. Other ADHD medications may have different effects on growth trajectories, and further research is needed to explore these potential differences.

Conclusion

In conclusion, the study highlights the variance in weight trajectories among youth with ADHD when prescribed different medications. The findings underscore the importance of careful consideration and personalized treatment approaches for this population. Healthcare professionals and parents alike should engage in open and informed discussions to make well-informed decisions regarding medication options, always weighing the potential benefits against any potential risks or side effects. Future research can continue to shed light on this topic, providing clinicians and families with more comprehensive insights to guide ADHD treatment decisions.